CLN Article
Table 2
Treatment Protocols Using Various Dosing Regimens for Chronic Hepatitis C
|
Treatment
|
Recommended Dose
|
Treatment Duration
|
|
| Mono | Interferon α-2b Interferon α-2a Interferon alfacon-1 |
6 MIU t.i.w. 3 MIU t.i.w. 9 µg t.i.w. |
48 weeks 72 weeks 24 – 48 weeks |
| Combo |
Interferon α-2b + PEG-IFN + |
3 MIU t.i.w. 180 µg or 1.5 µg/kg weekly |
24 weeks – Relapse 24 weeks - Genotypes 2/3 |
| Triple | PEG-INF + RBV + Telaprevir PEG-INF + RBV + Boceprevir |
TVR: 750 mg t.i.d. BOC: 800 mg t.i.d. |
12 wks triple + 36 wks combo 4 wks combo + 32 wks triple + 12 wks combo |
|
Abbreviations: MIU=million international units; t.i.w.=three times weekly; t.i.d.=thee times daily *Dosage based on body weight: patients weighing < than or equal to 75 kg receive 1,000 mg oral ribavirin, patients weighing >75 kg receive 1,200 mg oral ribavirin. FDA approved 800 mg daily dose of ribavirin when used with PEG-IFN, especially in patients who weigh <65 kg. |
|||