Khosrow Adeli, PhD, FCACB, DABCC, FADLM is a division head of clinical biochemistry in the department of paediatric laboratory medicine at The Hospital for Sick Children, professor in the department of laboratory medicine and pathobiology at the University of Toronto, and senior scientist at the SickKids Research Institute. Additionally, he is the principal investigator of the CALIPER program and the past president of the IFCC Organization.
He has been actively involved in both basic and clinical laboratory research since 1988 and has published over 200 articles and abstracts to date. He has received several national and international awards for research excellence including the Merck Senior Investigator Award of the Canadian Lipoprotein Conference (2008), the Canadian Society of Clinical Chemistry National Award for outstanding contributions to clinical chemistry (2006), Canadian Academy of Clinical Biochemistry National Award (2004), the Canadian Society of Clinical Chemistry Research Excellence Award (1999), Bristol-Meyers Squib Young Investigator (1995), the Merck Senior Investigator Award (1997), and the Simon-Pierre Noel Award (2001) from the Canadian Lipoprotein Conference.
His basic research program is focused on the link between insulin resistant diabetes and dysregulation of lipoprotein metabolism. His group has particularly focused on elucidating the molecular mechanisms linking diet-induced insulin resistance and metabolic dyslipidemia. His laboratory is employing animal models of insulin resistance to investigate the molecular mechanisms mediating the diabetogenic effect of fructose-rich diets, mechanisms of fructose-induced hepatic insulin resistance, and pathways leading to hepatic and intestinal lipogenesis and lipoprotein dysregulation. Dr. Adeli holds research operating grants from the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), the Heart and Stroke Foundation of Ontario, Merck, AstraZeneca, Pfizer, Abbott Diagnostics, Roche Diagnostics, Resverlogix, and Amgen.
Dr. Adeli is also active in clinical chemistry research and has been involved in a number of projects on diagnostic test development projects. He is the principal investigator of the CALIPER (Canadian Laboratory Initiative on Pediatric Reference Interval Database) project aimed at the establishment of a laboratory reference interval database for biomarkers of pediatric disease. This is a national initiative involving a network of several clinical laboratory investigators from pediatric health care centers from across Canada. Standardized age- and gender-specific reference intervals are being established involving pediatric health care centers across Canada. This valuable database will also be useful to pediatric health care centers worldwide as significant gaps exist in the available database in both developed and developing countries.